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Activation of mTORC1 in chondrocytes does not affect proliferation or differentiation, but causes the resting zone of the growth plate to become disordered

There are several pitfalls associated with research based on transgenic mice. Here, we describe our interpretation and analysis of mTORC1 activation in growth plate chondrocytes and compare these to a recent publication (Yan et al., Nature Communications 2016, 7:11151). Both laboratories employed TS...

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Dades bibliogràfiques
Publicat a:Bone Rep
Autors principals: Newton, Phillip T., Xie, Meng, Medvedeva, Ekaterina V., Sävendahl, Lars, Chagin, Andrei S.
Format: Artigo
Idioma:Inglês
Publicat: Elsevier 2018
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6020113/
https://ncbi.nlm.nih.gov/pubmed/29955624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bonr.2018.02.006
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