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Targeted deletion of Atg5 in chondrocytes promotes age-related osteoarthritis
OBJECTIVES: It has been suggested that the lysosomal recycling process called macro-autophagy plays a role in osteoarthritis development. We thus decided to genetically ablate the autophagy-indispensable Atg5 gene specifically in chondrocytes and analyse the development of osteoarthritis upon aging...
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| Опубликовано в: : | Ann Rheum Dis |
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| Главные авторы: | , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
BMJ Publishing Group
2016
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4789686/ https://ncbi.nlm.nih.gov/pubmed/26438374 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/annrheumdis-2015-207742 |
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