Targeted deletion of Atg5 in chondrocytes promotes age-related osteoarthritis

OBJECTIVES: It has been suggested that the lysosomal recycling process called macro-autophagy plays a role in osteoarthritis development. We thus decided to genetically ablate the autophagy-indispensable Atg5 gene specifically in chondrocytes and analyse the development of osteoarthritis upon aging...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Ann Rheum Dis
Egile Nagusiak: Bouderlique, Thibault, Vuppalapati, Karuna K, Newton, Phillip T, Li, Lei, Barenius, Björn, Chagin, Andrei S
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: BMJ Publishing Group 2016
Gaiak:
Basic and Translational Research
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4789686/
https://ncbi.nlm.nih.gov/pubmed/26438374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/annrheumdis-2015-207742
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