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Targeted deletion of Atg5 in intestinal epithelial cells promotes dextran sodium sulfate-induced colitis

Autophagy-associated genes have been identified as susceptible loci for inflammatory bowel disease. We investigated the role of a core autophagy factor, Atg5, in the development of dextran sodium sulfate (DSS)-induced colitis. Intestinal epithelial cell (IEC)-specific Atg5 gene deficient mice (Atg5(...

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Bibliografiske detaljer
Udgivet i:J Clin Biochem Nutr
Main Authors: Nishino, Kyohei, Nishida, Atsushi, Inatomi, Osamu, Imai, Takayuki, Kume, Shinji, Kawahara, Masahiro, Maegawa, Hiroshi, Andoh, Akira
Format: Artigo
Sprog:Inglês
Udgivet: the Society for Free Radical Research Japan 2021
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Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8045999/
https://ncbi.nlm.nih.gov/pubmed/33879967
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3164/jcbn.20-90
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