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TARDBP/TDP-43 regulates autophagy in both MTORC1-dependent and MTORC1-independent manners
In a recent paper we addressed the mechanism by which defective autophagy contributes to TARDBP/TDP-43-mediated neurodegenerative disorders. We demonstrated that TARDBP regulates MTORC1-TFEB signaling by targeting RPTOR/raptor, a key component and an adaptor protein of MTORC1. Loss of TARDBP decreas...
Αποθηκεύτηκε σε:
| Τόπος έκδοσης: | Autophagy |
|---|---|
| Κύριοι συγγραφείς: | , , , , , , |
| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
Taylor & Francis
2016
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4836031/ https://ncbi.nlm.nih.gov/pubmed/27050460 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2016.1151596 |
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