TARDBP/TDP-43 regulates autophagy in both MTORC1-dependent and MTORC1-independent manners

In a recent paper we addressed the mechanism by which defective autophagy contributes to TARDBP/TDP-43-mediated neurodegenerative disorders. We demonstrated that TARDBP regulates MTORC1-TFEB signaling by targeting RPTOR/raptor, a key component and an adaptor protein of MTORC1. Loss of TARDBP decreas...

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Detalles Bibliográficos
Publicado en:Autophagy
Autores principales: Ying, Zheng, Xia, Qin, Hao, Zongbing, Xu, Delai, Wang, Mingmei, Wang, Hongfeng, Wang, Guanghui
Formato: Artigo
Lenguaje:Inglês
Publicado: Taylor & Francis 2016
Materias:
Autophagic Puncta
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4836031/
https://ncbi.nlm.nih.gov/pubmed/27050460
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2016.1151596
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