Deubiquitinase inhibition by WP1130 leads to ULK1 aggregation and blockade of autophagy

Autophagy represents an intracellular degradation process which is involved in both regular cell homeostasis and disease settings. In recent years, the molecular machinery governing this process has been elucidated. The ULK1 kinase complex consisting of the serine/threonine protein kinase ULK1 and t...

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Bibliografiske detaljer
Udgivet i:Autophagy
Main Authors: Drießen, Stefan, Berleth, Niklas, Friesen, Olena, Löffler, Antje S, Böhler, Philip, Hieke, Nora, Stuhldreier, Fabian, Peter, Christoph, Schink, Kay O, Schultz, Sebastian W, Stenmark, Harald, Holland, Petter, Simonsen, Anne, Wesselborg, Sebastian, Stork, Björn
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2015
Fag:
Basic Brief Report
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4590650/
https://ncbi.nlm.nih.gov/pubmed/26207339
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2015.1067359
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