Deubiquitinase inhibition by WP1130 leads to ULK1 aggregation and blockade of autophagy

Autophagy represents an intracellular degradation process which is involved in both regular cell homeostasis and disease settings. In recent years, the molecular machinery governing this process has been elucidated. The ULK1 kinase complex consisting of the serine/threonine protein kinase ULK1 and t...

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Detalhes bibliográficos
Publicado no:Autophagy
Main Authors: Drießen, Stefan, Berleth, Niklas, Friesen, Olena, Löffler, Antje S, Böhler, Philip, Hieke, Nora, Stuhldreier, Fabian, Peter, Christoph, Schink, Kay O, Schultz, Sebastian W, Stenmark, Harald, Holland, Petter, Simonsen, Anne, Wesselborg, Sebastian, Stork, Björn
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2015
Assuntos:
Basic Brief Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4590650/
https://ncbi.nlm.nih.gov/pubmed/26207339
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2015.1067359
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