Deubiquitinase inhibition by WP1130 leads to ULK1 aggregation and blockade of autophagy

Autophagy represents an intracellular degradation process which is involved in both regular cell homeostasis and disease settings. In recent years, the molecular machinery governing this process has been elucidated. The ULK1 kinase complex consisting of the serine/threonine protein kinase ULK1 and t...

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Detalles Bibliográficos
Publicado en:Autophagy
Autores principales: Drießen, Stefan, Berleth, Niklas, Friesen, Olena, Löffler, Antje S, Böhler, Philip, Hieke, Nora, Stuhldreier, Fabian, Peter, Christoph, Schink, Kay O, Schultz, Sebastian W, Stenmark, Harald, Holland, Petter, Simonsen, Anne, Wesselborg, Sebastian, Stork, Björn
Formato: Artigo
Lenguaje:Inglês
Publicado: Taylor & Francis 2015
Materias:
Basic Brief Report
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4590650/
https://ncbi.nlm.nih.gov/pubmed/26207339
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2015.1067359
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