Chimeric antigen receptor T cells targeting HERV-K inhibit breast cancer and its metastasis through downregulation of Ras

We have previously reported that human endogenous retrovirus-K (HERV-K) envelope (env) protein is a tumor-associated antigen (TAA) for cancer vaccines, and that its antibodies (mAbs) possess antitumor activity against cancer. In this study, a chimeric antigen receptor (CAR) specific for HERV-K env p...

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Détails bibliographiques
Publié dans:Oncoimmunology
Auteurs principaux: Zhou, Fuling, Krishnamurthy, Janani, Wei, Yongchang, Li, Ming, Hunt, Kelly, Johanning, Gary L, Cooper, Laurence JN, Wang-Johanning, Feng
Format: Artigo
Langue:Inglês
Publié: Taylor & Francis 2015
Sujets:
Original Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4589998/
https://ncbi.nlm.nih.gov/pubmed/26451325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2015.1047582
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