Genetic Engineering of T cells to Target HERV-K, an Ancient Retrovirus on Melanoma

PURPOSE: The human endogenous retrovirus (HERV-K) envelope (env) protein is a tumor- associated antigen expressed on melanoma, but not normal cells. This study was designed to engineer a chimeric antigen receptor (CAR) on T cell surface, such that they target tumors in advanced stages of melanoma. E...

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Publicat a:Clin Cancer Res
Autors principals: Krishnamurthy, Janani, Rabinovich, Brian A., Mi, Tiejuan, Switzer, Kirsten C., Olivares, Simon, Maiti, Sourindra N., Plummer, Joshua B., Singh, Harjeet, Kumaresan, Pappanaicken R., Huls, Helen M., Wang-Johanning, Feng, Cooper, Laurence J.N.
Format: Artigo
Idioma:Inglês
Publicat: 2015
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4506228/
https://ncbi.nlm.nih.gov/pubmed/25829402
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-14-3197
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