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Recruitment of RAG1 and RAG2 to Chromatinized DNA during V(D)J Recombination

V(D)J recombination is initiated by the binding of the RAG1 and RAG2 proteins to recombination signal sequences (RSSs) that consist of conserved heptamer and nonamer sequences separated by a spacer of either 12 or 23 bp. Here, we used RAG-inducible pro-B v-Abl cell lines in conjunction with chromati...

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Pubblicato in:Mol Cell Biol
Autori principali: Shetty, Keerthi, Schatz, David G.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2015
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4589606/
https://ncbi.nlm.nih.gov/pubmed/26303526
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00219-15
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