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Single-molecule analysis of RAG-mediated V(D)J DNA cleavage

The recombination-activating gene products, RAG1 and RAG2, initiate V(D)J recombination during lymphocyte development by cleaving DNA adjacent to conserved recombination signal sequences (RSSs). The reaction involves DNA binding, synapsis, and cleavage at two RSSs located on the same DNA molecule an...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Lovely, Geoffrey A., Brewster, Robert C., Schatz, David G., Baltimore, David, Phillips, Rob
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2015
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4394307/
https://ncbi.nlm.nih.gov/pubmed/25831509
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1503477112
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