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Autoinhibition of DNA cleavage mediated by RAG1 and RAG2 is overcome by an epigenetic signal in V(D)J recombination
Gene assembly of the variable domain of antigen receptors is initiated by DNA cleavage by the RAG1–RAG2 protein complex at sites flanking V, D, and J gene segments. Double-strand breaks are produced via a single-strand nick that is converted to a hairpin end on coding DNA and a blunt end on the neig...
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| Main Authors: | , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
National Academy of Sciences
2010
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3012499/ https://ncbi.nlm.nih.gov/pubmed/21149691 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1014958107 |
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