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DNA Cleavage Activity of the V(D)J Recombination Protein RAG1 Is Autoregulated

RAG1 and RAG2 catalyze the first DNA cleavage steps in V(D)J recombination. We demonstrate that the isolated central domain of RAG1 has inherent single-stranded (ss) DNA cleavage activity, which does not require, but is enhanced by, RAG2. The central domain, therefore, contains the active-site resid...

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Autores principales: De, Pallabi, Peak, Mandy M., Rodgers, Karla K.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2004
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC444861/
https://ncbi.nlm.nih.gov/pubmed/15254250
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.15.6850-6860.2004
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