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DNA Cleavage Activity of the V(D)J Recombination Protein RAG1 Is Autoregulated

RAG1 and RAG2 catalyze the first DNA cleavage steps in V(D)J recombination. We demonstrate that the isolated central domain of RAG1 has inherent single-stranded (ss) DNA cleavage activity, which does not require, but is enhanced by, RAG2. The central domain, therefore, contains the active-site resid...

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Detalhes bibliográficos
Main Authors: De, Pallabi, Peak, Mandy M., Rodgers, Karla K.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2004
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC444861/
https://ncbi.nlm.nih.gov/pubmed/15254250
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.15.6850-6860.2004
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