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DNA Cleavage Activity of the V(D)J Recombination Protein RAG1 Is Autoregulated

RAG1 and RAG2 catalyze the first DNA cleavage steps in V(D)J recombination. We demonstrate that the isolated central domain of RAG1 has inherent single-stranded (ss) DNA cleavage activity, which does not require, but is enhanced by, RAG2. The central domain, therefore, contains the active-site resid...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: De, Pallabi, Peak, Mandy M., Rodgers, Karla K.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: American Society for Microbiology 2004
विषय:
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC444861/
https://ncbi.nlm.nih.gov/pubmed/15254250
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.15.6850-6860.2004
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