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DNA Cleavage Activity of the V(D)J Recombination Protein RAG1 Is Autoregulated
RAG1 and RAG2 catalyze the first DNA cleavage steps in V(D)J recombination. We demonstrate that the isolated central domain of RAG1 has inherent single-stranded (ss) DNA cleavage activity, which does not require, but is enhanced by, RAG2. The central domain, therefore, contains the active-site resid...
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| 主要な著者: | , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American Society for Microbiology
2004
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC444861/ https://ncbi.nlm.nih.gov/pubmed/15254250 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.15.6850-6860.2004 |
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