Nasal Administration of Cholera Toxin as a Mucosal Adjuvant Damages the Olfactory System in Mice

Cholera toxin (CT) induces severe diarrhea in humans but acts as an adjuvant to enhance immune responses to vaccines when administered orally. Nasally administered CT also acts as an adjuvant, but CT and CT derivatives, including the B subunit of CT (CTB), are taken up from the olfactory epithelium...

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Библиографические подробности
Опубликовано в: :PLoS One
Главные авторы: Fukuyama, Yoshiko, Okada, Kazunari, Yamaguchi, Masahiro, Kiyono, Hiroshi, Mori, Kensaku, Yuki, Yoshikazu
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2015
Предметы:
Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4589288/
https://ncbi.nlm.nih.gov/pubmed/26422280
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0139368
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