Nasal Administration of Cholera Toxin as a Mucosal Adjuvant Damages the Olfactory System in Mice

Cholera toxin (CT) induces severe diarrhea in humans but acts as an adjuvant to enhance immune responses to vaccines when administered orally. Nasally administered CT also acts as an adjuvant, but CT and CT derivatives, including the B subunit of CT (CTB), are taken up from the olfactory epithelium...

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Dades bibliogràfiques
Publicat a:PLoS One
Autors principals: Fukuyama, Yoshiko, Okada, Kazunari, Yamaguchi, Masahiro, Kiyono, Hiroshi, Mori, Kensaku, Yuki, Yoshikazu
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2015
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4589288/
https://ncbi.nlm.nih.gov/pubmed/26422280
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0139368
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