Nod2-mediated recognition of the microbiota is critical for mucosal adjuvant activity of cholera toxin

Cholera toxin (CT) is a potent adjuvant for inducing mucosal immune responses. However, the mechanism by which CT induces adjuvant activity remains unclear. Here we show that the microbiota is critical for inducing antigen-specific IgG production after intranasal immunization. After mucosal vaccinat...

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Gepubliceerd in:Nat Med
Hoofdauteurs: Kim, Donghyun, Kim, Yun-Gi, Seo, Sang-Uk, Kim, Dong-Jae, Kamada, Nobuhiko, Prescott, Dave, Philpott, Dana J., Rosenstiel, Philip, Inohara, Naohiro, Núñez, Gabriel
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2016
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4860092/
https://ncbi.nlm.nih.gov/pubmed/27064448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.4075
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