Decreased affinity for efflux transporters increases brain penetrance and molecular targeting of a PI3K/mTOR inhibitor in a mouse model of glioblastoma

BACKGROUND: Targeting drug delivery to invasive glioma cells is a particularly difficult challenge because these cells lie behind an intact blood-brain barrier (BBB) that can be observed using multimodality imaging. BBB-associated efflux transporters such as P-glycoprotein (P-gp) and breast cancer r...

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Опубликовано в: :Neuro Oncol
Главные авторы: Becker, Chani M., Oberoi, Rajneet K., McFarren, Stephan J., Muldoon, Daniel M., Pafundi, Deanna H., Pokorny, Jenny L., Brinkmann, Debra H., Ohlfest, John R., Sarkaria, Jann N., Largaespada, David A., Elmquist, William F.
Формат: Artigo
Язык:Inglês
Опубликовано: Oxford University Press 2015
Предметы:
Basic and Translational Investigations
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4588756/
https://ncbi.nlm.nih.gov/pubmed/25972455
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nov081
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