Broadly Neutralizing Antibody 8ANC195 Recognizes Closed and Open States of HIV-1 Env

The HIV-1 envelope (Env) spike contains limited epitopes for broadly neutralizing antibodies (bNAbs); thus, most neutralizing antibodies are strain specific. The 8ANC195 epitope, defined by crystal and electron microscopy (EM) structures of bNAb 8ANC195 complexed with monomeric gp120 and trimeric En...

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Bibliografiska uppgifter
I publikationen:Cell
Huvudupphovsmän: Scharf, Louise, Wang, Haoqing, Gao, Han, Chen, Songye, McDowall, Alasdair W., Bjorkman, Pamela J.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2015
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4587768/
https://ncbi.nlm.nih.gov/pubmed/26359989
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2015.08.035
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