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Neutrophil Extracellular Trap-Related Extracellular Histones Cause Vascular Necrosis in Severe GN
Severe GN involves local neutrophil extracellular trap (NET) formation. We hypothesized a local cytotoxic effect of NET-related histone release in necrotizing GN. In vitro, histones from calf thymus or histones released by neutrophils undergoing NETosis killed glomerular endothelial cells, podocytes...
Shranjeno v:
| izdano v: | J Am Soc Nephrol |
|---|---|
| Main Authors: | , , , , , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
American Society of Nephrology
2015
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4587690/ https://ncbi.nlm.nih.gov/pubmed/25644111 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2014070673 |
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