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Histones and Neutrophil Extracellular Traps Enhance Tubular Necrosis and Remote Organ Injury in Ischemic AKI
Severe AKI is often associated with multiorgan dysfunction, but the mechanisms of this remote tissue injury are unknown. We hypothesized that renal necroinflammation releases cytotoxic molecules that may cause remote organ damage. In hypoxia-induced tubular epithelial cell necrosis in vitro, histone...
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| Foilsithe in: | J Am Soc Nephrol |
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| Main Authors: | , , , , , , , , , , , , |
| Formáid: | Artigo |
| Teanga: | Inglês |
| Foilsithe: |
American Society of Nephrology
2017
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| Ábhair: | |
| Rochtain Ar Líne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5461800/ https://ncbi.nlm.nih.gov/pubmed/28073931 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2016080925 |
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