Histones and Neutrophil Extracellular Traps Enhance Tubular Necrosis and Remote Organ Injury in Ischemic AKI

Severe AKI is often associated with multiorgan dysfunction, but the mechanisms of this remote tissue injury are unknown. We hypothesized that renal necroinflammation releases cytotoxic molecules that may cause remote organ damage. In hypoxia-induced tubular epithelial cell necrosis in vitro, histone...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Am Soc Nephrol
Prif Awduron: Nakazawa, Daigo, Kumar, Santhosh V., Marschner, Julian, Desai, Jyaysi, Holderied, Alexander, Rath, Lukas, Kraft, Franziska, Lei, Yutian, Fukasawa, Yuichiro, Moeckel, Gilbert W., Angelotti, Maria Lucia, Liapis, Helen, Anders, Hans-Joachim
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society of Nephrology 2017
Pynciau:
Basic Research
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5461800/
https://ncbi.nlm.nih.gov/pubmed/28073931
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2016080925
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