Histones and Neutrophil Extracellular Traps Enhance Tubular Necrosis and Remote Organ Injury in Ischemic AKI

Severe AKI is often associated with multiorgan dysfunction, but the mechanisms of this remote tissue injury are unknown. We hypothesized that renal necroinflammation releases cytotoxic molecules that may cause remote organ damage. In hypoxia-induced tubular epithelial cell necrosis in vitro, histone...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:J Am Soc Nephrol
मुख्य लेखकों: Nakazawa, Daigo, Kumar, Santhosh V., Marschner, Julian, Desai, Jyaysi, Holderied, Alexander, Rath, Lukas, Kraft, Franziska, Lei, Yutian, Fukasawa, Yuichiro, Moeckel, Gilbert W., Angelotti, Maria Lucia, Liapis, Helen, Anders, Hans-Joachim
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: American Society of Nephrology 2017
विषय:
Basic Research
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC5461800/
https://ncbi.nlm.nih.gov/pubmed/28073931
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2016080925
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