Histones and Neutrophil Extracellular Traps Enhance Tubular Necrosis and Remote Organ Injury in Ischemic AKI

Severe AKI is often associated with multiorgan dysfunction, but the mechanisms of this remote tissue injury are unknown. We hypothesized that renal necroinflammation releases cytotoxic molecules that may cause remote organ damage. In hypoxia-induced tubular epithelial cell necrosis in vitro, histone...

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Foilsithe in:J Am Soc Nephrol
Main Authors: Nakazawa, Daigo, Kumar, Santhosh V., Marschner, Julian, Desai, Jyaysi, Holderied, Alexander, Rath, Lukas, Kraft, Franziska, Lei, Yutian, Fukasawa, Yuichiro, Moeckel, Gilbert W., Angelotti, Maria Lucia, Liapis, Helen, Anders, Hans-Joachim
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society of Nephrology 2017
Ábhair:
Basic Research
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5461800/
https://ncbi.nlm.nih.gov/pubmed/28073931
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2016080925
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