Neutrophil Extracellular Trap-Related Extracellular Histones Cause Vascular Necrosis in Severe GN

Severe GN involves local neutrophil extracellular trap (NET) formation. We hypothesized a local cytotoxic effect of NET-related histone release in necrotizing GN. In vitro, histones from calf thymus or histones released by neutrophils undergoing NETosis killed glomerular endothelial cells, podocytes...

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Veröffentlicht in:J Am Soc Nephrol
Hauptverfasser: Kumar, Santhosh V.R., Kulkarni, Onkar P., Mulay, Shrikant R., Darisipudi, Murthy N., Romoli, Simone, Thomasova, Dana, Scherbaum, Christina R., Hohenstein, Bernd, Hugo, Christian, Müller, Susanna, Liapis, Helen, Anders, Hans-Joachim
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Nephrology 2015
Schlagworte:
Basic Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4587690/
https://ncbi.nlm.nih.gov/pubmed/25644111
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2014070673
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