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Uromodulin Triggers IL-1β–Dependent Innate Immunity via the NLRP3 Inflammasome
Uromodulin/Tamm-Horsfall protein is not immunostimulatory in the tubular lumen, but through unknown mechanisms it can activate dendritic cells and promote inflammation in the renal interstitium. Here, we noted that uromodulin isolated from human urine aggregates to large, irregular clumps with a cry...
Αποθηκεύτηκε σε:
| Κύριοι συγγραφείς: | , , , , , , |
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| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
American Society of Nephrology
2012
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3482735/ https://ncbi.nlm.nih.gov/pubmed/22997256 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2012040338 |
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