Uromodulin Triggers IL-1β–Dependent Innate Immunity via the NLRP3 Inflammasome

Uromodulin/Tamm-Horsfall protein is not immunostimulatory in the tubular lumen, but through unknown mechanisms it can activate dendritic cells and promote inflammation in the renal interstitium. Here, we noted that uromodulin isolated from human urine aggregates to large, irregular clumps with a cry...

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Detalhes bibliográficos
Main Authors: Darisipudi, Murthy Narayana, Thomasova, Dana, Mulay, Shrikant R., Brech, Dorothee, Noessner, Elfriede, Liapis, Helen, Anders, Hans-Joachim
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Nephrology 2012
Assuntos:
Brief Communication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3482735/
https://ncbi.nlm.nih.gov/pubmed/22997256
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2012040338
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