Uromodulin Triggers IL-1β–Dependent Innate Immunity via the NLRP3 Inflammasome

Uromodulin/Tamm-Horsfall protein is not immunostimulatory in the tubular lumen, but through unknown mechanisms it can activate dendritic cells and promote inflammation in the renal interstitium. Here, we noted that uromodulin isolated from human urine aggregates to large, irregular clumps with a cry...

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Bibliographische Detailangaben
Hauptverfasser: Darisipudi, Murthy Narayana, Thomasova, Dana, Mulay, Shrikant R., Brech, Dorothee, Noessner, Elfriede, Liapis, Helen, Anders, Hans-Joachim
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Nephrology 2012
Schlagworte:
Brief Communication
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3482735/
https://ncbi.nlm.nih.gov/pubmed/22997256
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2012040338
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