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Polyene Macrolide Antifungal Drugs Trigger Interleukin-1β Secretion by Activating the NLRP3 Inflammasome

The use of antimycotic drugs in fungal infections is based on the concept that they suppress fungal growth by a direct killing effect. However, amphotericin and nystatin have been reported to also trigger interleukin-1β (IL-1β) secretion in monocytes but the molecular mechanism is unknown. Here we r...

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Hlavní autoři: Darisipudi, Murthy Narayana, Allam, Ramanjaneyulu, Rupanagudi, Khader Valli, Anders, Hans-Joachim
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2011
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3100296/
https://ncbi.nlm.nih.gov/pubmed/21625424
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0019588
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