Anti-GBM Glomerulonephritis Involves IL-1 but Is Independent of NLRP3/ASC Inflammasome-Mediated Activation of Caspase-1

IL-1β and IL-18 are proinflammatory cytokines that contribute to renal immune complex disease, but whether IL-1β and IL-18 are mediators of intrinsic glomerular inflammation is unknown. In contrast to other cytokines the secretion of IL-1β and IL-18 requires a second stimulus that activates the infl...

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Main Authors: Lichtnekert, Julia, Kulkarni, Onkar P., Mulay, Shrikant R., Rupanagudi, Khader Valli, Ryu, Mi, Allam, Ramanjaneyulu, Vielhauer, Volker, Muruve, Dan, Lindenmeyer, Maja T., Cohen, Clemens D., Anders, Hans-Joachim
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2011
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3203143/
https://ncbi.nlm.nih.gov/pubmed/22046355
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0026778
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