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Calcium oxalate crystals induce renal inflammation by NLRP3-mediated IL-1β secretion

Nephrocalcinosis, acute calcium oxalate (CaOx) nephropathy, and renal stone disease can lead to inflammation and subsequent renal failure, but the underlying pathological mechanisms remain elusive. Other crystallopathies, such as gout, atherosclerosis, and asbestosis, trigger inflammation and tissue...

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Hlavní autoři: Mulay, Shrikant R., Kulkarni, Onkar P., Rupanagudi, Khader V., Migliorini, Adriana, Darisipudi, Murthy N., Vilaysane, Akosua, Muruve, Daniel, Shi, Yan, Munro, Fay, Liapis, Helen, Anders, Hans-Joachim
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2012
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3533282/
https://ncbi.nlm.nih.gov/pubmed/23221343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI63679
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