Uromodulin Triggers IL-1β–Dependent Innate Immunity via the NLRP3 Inflammasome

Uromodulin/Tamm-Horsfall protein is not immunostimulatory in the tubular lumen, but through unknown mechanisms it can activate dendritic cells and promote inflammation in the renal interstitium. Here, we noted that uromodulin isolated from human urine aggregates to large, irregular clumps with a cry...

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Autori principali: Darisipudi, Murthy Narayana, Thomasova, Dana, Mulay, Shrikant R., Brech, Dorothee, Noessner, Elfriede, Liapis, Helen, Anders, Hans-Joachim
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Nephrology 2012
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Brief Communication
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3482735/
https://ncbi.nlm.nih.gov/pubmed/22997256
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2012040338
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