Uromodulin Triggers IL-1β–Dependent Innate Immunity via the NLRP3 Inflammasome

Uromodulin/Tamm-Horsfall protein is not immunostimulatory in the tubular lumen, but through unknown mechanisms it can activate dendritic cells and promote inflammation in the renal interstitium. Here, we noted that uromodulin isolated from human urine aggregates to large, irregular clumps with a cry...

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Bibliografiska uppgifter
Huvudupphovsmän: Darisipudi, Murthy Narayana, Thomasova, Dana, Mulay, Shrikant R., Brech, Dorothee, Noessner, Elfriede, Liapis, Helen, Anders, Hans-Joachim
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society of Nephrology 2012
Ämnen:
Brief Communication
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3482735/
https://ncbi.nlm.nih.gov/pubmed/22997256
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2012040338
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