Synergistic Activity of PARP Inhibition by Talazoparib (BMN 673) with Temozolomide in Pediatric Cancer Models in the Pediatric Preclinical Testing Program

BACKGROUND: Inhibitors of poly-ADP ribose polymerase (PARP), an enzyme involved in base excision repair (BER) have demonstrated single agent activity against tumors deficient in homologous repair processes. Ewing sarcoma cells are also sensitive to PARP inhibitors, although the mechanism is not unde...

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Veröffentlicht in:Clin Cancer Res
Hauptverfasser: Smith, Malcolm A., Reynolds, Patrick, Kang, Min H., Kolb, E. Anders, Gorlick, Richard, Carol, C. Hernan, Lock, Richard B., Keir, Stephen T., Maris, John M., Billups, Catherine A., Lyalin, Dmitry, Kurmasheva, Raushan T., Houghton, Peter J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4587665/
https://ncbi.nlm.nih.gov/pubmed/25500058
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-14-2572
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