Synergistic Activity of PARP Inhibition by Talazoparib (BMN 673) with Temozolomide in Pediatric Cancer Models in the Pediatric Preclinical Testing Program

BACKGROUND: Inhibitors of poly-ADP ribose polymerase (PARP), an enzyme involved in base excision repair (BER) have demonstrated single agent activity against tumors deficient in homologous repair processes. Ewing sarcoma cells are also sensitive to PARP inhibitors, although the mechanism is not unde...

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Detalhes bibliográficos
Publicado no:Clin Cancer Res
Main Authors: Smith, Malcolm A., Reynolds, Patrick, Kang, Min H., Kolb, E. Anders, Gorlick, Richard, Carol, C. Hernan, Lock, Richard B., Keir, Stephen T., Maris, John M., Billups, Catherine A., Lyalin, Dmitry, Kurmasheva, Raushan T., Houghton, Peter J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4587665/
https://ncbi.nlm.nih.gov/pubmed/25500058
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-14-2572
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