Epithelial to Mesenchymal Transition induces cell cycle arrest and parenchymal damage in renal fibrosis

Kidney fibrosis is marked by an epithelial–to–mesenchymal transition (EMT) by tubular epithelial cells (TECs). Here we find that during renal fibrosis TECs acquire a partial EMT program during which they remain associated with their basement membrane and express markers of both epithelial and mesenc...

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Udgivet i:Nat Med
Main Authors: Lovisa, Sara, LeBleu, Valerie S., Tampe, Björn, Sugimoto, Hikaru, Vadnagara, Komal, Carstens, Julienne L., Wu, Chia–Chin, Hagos, Yohannes, Burckhardt, Birgitta C., Pentcheva–Hoang, Tsvetelina, Nischal, Hersharan, Allison, James P., Zeisberg, Michael, Kalluri, Raghu
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4587560/
https://ncbi.nlm.nih.gov/pubmed/26236991
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.3902
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