Epithelial to Mesenchymal Transition induces cell cycle arrest and parenchymal damage in renal fibrosis

Kidney fibrosis is marked by an epithelial–to–mesenchymal transition (EMT) by tubular epithelial cells (TECs). Here we find that during renal fibrosis TECs acquire a partial EMT program during which they remain associated with their basement membrane and express markers of both epithelial and mesenc...

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Publicado no:Nat Med
Principais autores: Lovisa, Sara, LeBleu, Valerie S., Tampe, Björn, Sugimoto, Hikaru, Vadnagara, Komal, Carstens, Julienne L., Wu, Chia–Chin, Hagos, Yohannes, Burckhardt, Birgitta C., Pentcheva–Hoang, Tsvetelina, Nischal, Hersharan, Allison, James P., Zeisberg, Michael, Kalluri, Raghu
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4587560/
https://ncbi.nlm.nih.gov/pubmed/26236991
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.3902
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