Requirement for transient metal ions revealed through computational analysis for DNA polymerase going in reverse

DNA polymerases facilitate faithful insertion of nucleotides, a central reaction occurring during DNA replication and repair. DNA synthesis (forward reaction) is “balanced,” as dictated by the chemical equilibrium by the reverse reaction of pyrophosphorolysis. Two closely spaced divalent metal ions...

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Detaylı Bibliyografya
Yayımlandı:Proc Natl Acad Sci U S A
Asıl Yazarlar: Perera, Lalith, Freudenthal, Bret D., Beard, William A., Shock, David D., Pedersen, Lee G., Wilson, Samuel H.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2015
Konular:
PNAS Plus
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4586863/
https://ncbi.nlm.nih.gov/pubmed/26351676
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1511207112
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