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Uncovering the Polymerase-induced Cytotoxicty of an Oxidized Nucleotide
Oxidative stress promotes genomic instability and human diseases(1). A common oxidized nucleoside is 8-oxo-7,8-dihydro-2’-deoxyguanosine found both in DNA (8-oxo-G) and as a free nucleotide (8-oxo-dGTP)(2,3). Nucleotide pools are especially vulnerable to oxidative damage(4). Therefore cells encode a...
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| Veröffentlicht in: | Nature |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2014
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4312183/ https://ncbi.nlm.nih.gov/pubmed/25409153 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature13886 |
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