Uncovering the Polymerase-induced Cytotoxicty of an Oxidized Nucleotide

Oxidative stress promotes genomic instability and human diseases(1). A common oxidized nucleoside is 8-oxo-7,8-dihydro-2’-deoxyguanosine found both in DNA (8-oxo-G) and as a free nucleotide (8-oxo-dGTP)(2,3). Nucleotide pools are especially vulnerable to oxidative damage(4). Therefore cells encode a...

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Detalhes bibliográficos
Publicado no:Nature
Main Authors: Freudenthal, Bret D., Beard, William A., Perera, Lalith, Shock, David D., Kim, Taejin, Schlick, Tamar, Wilson, Samuel H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4312183/
https://ncbi.nlm.nih.gov/pubmed/25409153
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature13886
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