A chimeric prokaryotic pentameric ligand–gated channel reveals distinct pathways of activation

Recent high resolution structures of several pentameric ligand–gated ion channels have provided unprecedented details of their molecular architecture. However, the conformational dynamics and structural rearrangements that underlie gating and allosteric modulation remain poorly understood. We used a...

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Detalles Bibliográficos
Publicado en:J Gen Physiol
Autores principales: Schmandt, Nicolaus, Velisetty, Phanindra, Chalamalasetti, Sreevatsa V., Stein, Richard A., Bonner, Ross, Talley, Lauren, Parker, Mark D., Mchaourab, Hassane S., Yee, Vivien C., Lodowski, David T., Chakrapani, Sudha
Formato: Artigo
Lenguaje:Inglês
Publicado: The Rockefeller University Press 2015
Materias:
Research Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4586589/
https://ncbi.nlm.nih.gov/pubmed/26415570
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.201511478
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