A chimeric prokaryotic pentameric ligand–gated channel reveals distinct pathways of activation

Recent high resolution structures of several pentameric ligand–gated ion channels have provided unprecedented details of their molecular architecture. However, the conformational dynamics and structural rearrangements that underlie gating and allosteric modulation remain poorly understood. We used a...

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Dades bibliogràfiques
Publicat a:J Gen Physiol
Autors principals: Schmandt, Nicolaus, Velisetty, Phanindra, Chalamalasetti, Sreevatsa V., Stein, Richard A., Bonner, Ross, Talley, Lauren, Parker, Mark D., Mchaourab, Hassane S., Yee, Vivien C., Lodowski, David T., Chakrapani, Sudha
Format: Artigo
Idioma:Inglês
Publicat: The Rockefeller University Press 2015
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4586589/
https://ncbi.nlm.nih.gov/pubmed/26415570
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.201511478
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