A chimeric prokaryotic pentameric ligand–gated channel reveals distinct pathways of activation

Recent high resolution structures of several pentameric ligand–gated ion channels have provided unprecedented details of their molecular architecture. However, the conformational dynamics and structural rearrangements that underlie gating and allosteric modulation remain poorly understood. We used a...

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Bibliografiske detaljer
Udgivet i:J Gen Physiol
Main Authors: Schmandt, Nicolaus, Velisetty, Phanindra, Chalamalasetti, Sreevatsa V., Stein, Richard A., Bonner, Ross, Talley, Lauren, Parker, Mark D., Mchaourab, Hassane S., Yee, Vivien C., Lodowski, David T., Chakrapani, Sudha
Format: Artigo
Sprog:Inglês
Udgivet: The Rockefeller University Press 2015
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4586589/
https://ncbi.nlm.nih.gov/pubmed/26415570
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.201511478
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