O-GlcNAcylation regulates ischemia-induced neuronal apoptosis through AKT signaling

Apoptosis plays an important role in neural development and neurological disorders. In this study, we found that O-GlcNAcylation, a unique protein posttranslational modification with O-linked β-N-acetylglucosamine (GlcNAc), promoted apoptosis through attenuating phosphorylation/activation of AKT and...

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Vydáno v:Sci Rep
Hlavní autoři: Shi, Jianhua, Gu, Jin-hua, Dai, Chun-ling, Gu, Jianlan, Jin, Xiaoxia, Sun, Jianming, Iqbal, Khalid, Liu, Fei, Gong, Cheng-Xin
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2015
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4585968/
https://ncbi.nlm.nih.gov/pubmed/26412745
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep14500
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