O‐GlcNAcylation of protein kinase A catalytic subunits enhances its activity: a mechanism linked to learning and memory deficits in Alzheimer's disease

Alzheimer's disease (AD) is characterized clinically by memory loss and cognitive decline. Protein kinase A (PKA)‐CREB signaling plays a critical role in learning and memory. It is known that glucose uptake and O‐GlcNAcylation are reduced in AD brain. In this study, we found that PKA catalytic...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Aging Cell
Prif Awduron: Xie, Shutao, Jin, Nana, Gu, Jianlan, Shi, Jianhua, Sun, Jianming, Chu, Dandan, Zhang, Liang, Dai, Chun‐ling, Gu, Jin‐hua, Gong, Cheng‐Xin, Iqbal, Khalid, Liu, Fei
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: John Wiley and Sons Inc. 2016
Pynciau:
Original Articles
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4854926/
https://ncbi.nlm.nih.gov/pubmed/26840030
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12449
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