O‐GlcNAcylation of protein kinase A catalytic subunits enhances its activity: a mechanism linked to learning and memory deficits in Alzheimer's disease

Alzheimer's disease (AD) is characterized clinically by memory loss and cognitive decline. Protein kinase A (PKA)‐CREB signaling plays a critical role in learning and memory. It is known that glucose uptake and O‐GlcNAcylation are reduced in AD brain. In this study, we found that PKA catalytic...

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Vydáno v:Aging Cell
Hlavní autoři: Xie, Shutao, Jin, Nana, Gu, Jianlan, Shi, Jianhua, Sun, Jianming, Chu, Dandan, Zhang, Liang, Dai, Chun‐ling, Gu, Jin‐hua, Gong, Cheng‐Xin, Iqbal, Khalid, Liu, Fei
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2016
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Original Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4854926/
https://ncbi.nlm.nih.gov/pubmed/26840030
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12449
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