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Rational Design of Orthogonal Multipolar Interactions with Fluorine in Protein–Ligand Complexes
[Image: see text] Multipolar interactions involving fluorine and the protein backbone have been frequently observed in protein–ligand complexes. Such fluorine–backbone interactions may substantially contribute to the high affinity of small molecule inhibitors. Here we found that introduction of trif...
שמור ב:
| הוצא לאור ב: | J Med Chem |
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| Main Authors: | , , , , , , |
| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
American Chemical
Society
2015
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| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4584387/ https://ncbi.nlm.nih.gov/pubmed/26288158 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.5b00975 |
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