Aberrant differentiation of Tsc2-deficient teratomas associated with activation of the mTORC1-TFE3 pathway

The model animal of renal cell carcinoma (RCC), the Eker rat, has a germline mutation in the tuberous sclerosis 2 (Tsc2) gene. Heterozygous mutants develop RCCs by second hit in the wild-type Tsc2 allele, whereas homozygous mutants are embryonic lethal. In the present study, a new cell differentiati...

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Udgivet i:Oncol Rep
Main Authors: KAWANO, HARUNA, ITO, YOSHITAKA, KANAI, FUMIO, NAKAMURA, ERI, TADA, NORIHIRO, TAKAI, SETSUO, HORIE, SHIGEO, KOBAYASHI, TOSHIYUKI, HINO, OKIO
Format: Artigo
Sprog:Inglês
Udgivet: D.A. Spandidos 2015
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4583534/
https://ncbi.nlm.nih.gov/pubmed/26352760
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/or.2015.4254
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