A germ-line Tsc1 mutation causes tumor development and embryonic lethality that are similar, but not identical to, those caused by Tsc2 mutation in mice

Tuberous sclerosis (TS) is characterized by the development of hamartomas in various organs and is caused by a germ-line mutation in either TSC1 or TSC2 tumor suppressor genes. From the symptomatic resemblance among TS patients, involvement of TSC1 and TSC2 products in a common pathway has been sugg...

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Detaylı Bibliyografya
Asıl Yazarlar: Kobayashi, Toshiyuki, Minowa, Osamu, Sugitani, Yoshinobu, Takai, Setsuo, Mitani, Hiroaki, Kobayashi, Etsuko, Noda, Tetsuo, Hino, Okio
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: The National Academy of Sciences 2001
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC37509/
https://ncbi.nlm.nih.gov/pubmed/11438694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.151033798
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