Intragenic Tsc2 Somatic Mutations as Knudson's Second Hit in Spontaneous and Chemically Induced Renal Carcinomas in the Eker Rat Model

We searched for the rat homologue of the human tuberous sclerosis (TSC2) gene mutations in loss of heterozygosity (LOH)‐negative Eker rat renal carcinomas (RCs) by polymerase chain reactionsingle‐strand conformational polymorphism (PCR‐SSCP) analysis using 45 primer sets covering all 41 coding exons...

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Publicado en:Jpn J Cancer Res
Main Authors: Kobayashi, Toshiyuki, Urakami, Shinji, Hirayama, Youko, Yamamoto, Toshiki, Nishizawa, Masae, Takahara, Tomoko, Kubo, Yoshiaki, Hino, Okio
Formato: Artigo
Idioma:Inglês
Publicado: Blackwell Publishing Ltd 1997
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5921374/
https://ncbi.nlm.nih.gov/pubmed/9140109
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1349-7006.1997.tb00375.x
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