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Aberrant differentiation of Tsc2-deficient teratomas associated with activation of the mTORC1-TFE3 pathway
The model animal of renal cell carcinoma (RCC), the Eker rat, has a germline mutation in the tuberous sclerosis 2 (Tsc2) gene. Heterozygous mutants develop RCCs by second hit in the wild-type Tsc2 allele, whereas homozygous mutants are embryonic lethal. In the present study, a new cell differentiati...
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| Izdano u: | Oncol Rep |
|---|---|
| Glavni autori: | , , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
D.A. Spandidos
2015
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4583534/ https://ncbi.nlm.nih.gov/pubmed/26352760 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/or.2015.4254 |
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