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Trametinib with and without pazopanib has potent preclinical activity in thyroid cancer

Multikinase inhibitors (MKIs) targeting VEGF receptors and other receptor tyrosine kinases have shown considerable activity in clinical trials of thyroid cancer. Thyroid cancer frequently exhibits activation of the RAS/RAF/MEK/ERK pathway. In other types of cancer, paradoxical ERK activation has eme...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:Oncol Rep
मुख्य लेखकों: BALL, DOUGLAS W., JIN, NING, XUE, PING, BHAN, SHEETAL, AHMED, SHABINA R., ROSEN, D. MARC, SCHAYOWITZ, ADAM, CLARK, DOUGLAS P., NELKIN, BARRY D.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: D.A. Spandidos 2015
विषय:
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC4583528/
https://ncbi.nlm.nih.gov/pubmed/26324075
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/or.2015.4225
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