Pazopanib and Trametinib as a Synergistic Strategy against Osteosarcoma: Preclinical Activity and Molecular Insights

Receptor tyrosine kinases (RTKs) inhibitors’ activity in advanced osteosarcoma is significant but short-lived. To prevent or at least delay drug resistance, we explored a vertical inhibition by combining drugs acting at different levels of the RTK pathways (pazopanib + trametinib). We studied pazopa...

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Bibliografiske detaljer
Udgivet i:Cancers (Basel)
Main Authors: Chiabotto, Giulia, Grignani, Giovanni, Todorovic, Maja, Martin, Valentina, Centomo, Maria Laura, Prola, Elisa, Giordano, Giorgia, Merlini, Alessandra, Miglio, Umberto, Berrino, Enrico, Napione, Lucia, Isella, Claudio, Capozzi, Federica, Basiricò, Marco, Marsero, Cristina, Gerardi, Ilaria, Venesio, Tiziana, Sangiolo, Dario, Aglietta, Massimo, D’Ambrosio, Lorenzo, Pignochino, Ymera
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7352822/
https://ncbi.nlm.nih.gov/pubmed/32531992
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers12061519
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