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Synergistic action of a RAF inhibitor and a dual PI-3 Kinase / mTOR inhibitor in thyroid cancer

PURPOSE: In thyroid cancer clinical trials, agents targeting VEGF receptors and RET, among other kinases, have led to partial responses but few complete or durable responses. The RAF-MEK-ERK and PI3K-AKT-mTOR signaling pathways are frequently activated in differentiated and medullary thyroid cancer...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Clin Cancer Res
Main Authors: Jin, Ning, Jiang, Tianyun, Rosen, David M., Nelkin, Barry D., Ball, Douglas W.
Format: Artigo
Jezik:Inglês
Izdano: 2011
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4828042/
https://ncbi.nlm.nih.gov/pubmed/21831957
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-11-0933
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