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A Phase I Trial of the VEGF Receptor Tyrosine Kinase Inhibitor Pazopanib in Combination with the MEK Inhibitor Trametinib in Advanced Solid Tumors and Differentiated Thyroid Cancers

PURPOSE: Differentiated thyroid cancer (DTC) responds to VEGF receptor inhibitors. VEGF signals through RAS/RAF/ MEK signaling. We evaluated the safety and efficacy of the VEGF receptor inhibitor pazopanib and MEK inhibitor trametinib in advanced solid tumors and DTC. PATIENTS AND METHODS: Patients...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Τόπος έκδοσης:Clin Cancer Res
Κύριοι συγγραφείς: Kurzrock, Razelle, Ball, Douglas W., Zahurak, Marianna L., Nelkin, Barry D., Subbiah, Vivek, Ahmed, Shabina, O’Connor, Ashley, Karunsena, Enusha, Parkinson, Rose M., Bishop, Justin A., Ha, Yoonji, Sharma, Rajni, Gocke, Christopher D., Zinner, Ralph, Rudek, Michelle A., Sherman, Steven I., Azad, Nilofer S.
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: 2019
Θέματα:
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7038784/
https://ncbi.nlm.nih.gov/pubmed/31186313
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-18-1881
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